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Challenges and Opportunities in the Management of HER2+ Metastatic Breast Cancer

Interactive Video Lecture

Targeted therapies have improved disease control and overall survival in patients with metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer, but integrating these agents into the clinic remains challenging. Oncology/hematology APPs need information on selecting therapies to optimize outcomes in patients with brain metastases, sequencing regimens, and educating patients about and managing toxicities. This video lecture features expert recommendations on using predictive biomarkers to guide use of targeted therapies and reviews monitoring for and managing toxicities associated with these agents.

Physician Assistants: maximum of 1.00 hours of AAPA Category 1 CME credits Registered Nurses: 1.00 Nursing contact hours, includes 1.00 hour of pharmacology credit

Released: March 08, 2022

Expiration: March 07, 2023

No longer available for credit.



Stephanie Andrews

Stephanie Andrews, MS, APRN-C

Nurse Practitioner
Department of Malignant Hematology
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida

Sara A. Hurvitz

Sara A. Hurvitz, MD

Professor of Medicine
Breast Cancer Clinical Trials Program
Division of Hematology/Oncology
David Geffen School of Medicine
Medical Director
Clinical Research Unit
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
Los Angeles, California


This program is cosupported by educational grants from Gilead Sciences, Inc. and Seagen Inc.

This activity is supported by an educational grant from Seagen Inc.

Provided by

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Seagen Inc.

Target Audience

Oncology NPs, PAs and nurses

Learning Objectives

Upon completion of this activity, participants should be able to:
  • Summarize healthcare disparities in breast cancer and their potential impact on treatment and outcomes

  • Identify appropriate therapies for patients with HER2-positive breast cancer based on clinical trial evidence, guideline recommendations, and patient and disease factors

  • Use recommended strategies to identify and manage adverse events of novel therapies for HER2-positive breast cancer

  • Apply current recommendations for cancer treatment during the COVID-19 pandemic, including COVID-19 vaccinations


All faculty and planners participating in continuing education activities sponsored by Practicing Clinicians Exchange (PCE) are required to disclose all financial relationships with ineligible companies. All relevant conflicts of interest are thoroughly vetted and mitigated according to PCE policy. In addition, all faculty are required to openly disclose any off-label, experimental, or investigational use of drugs or devices discussed in this activity. The faculty and Planning Committee have been advised that this activity must be free from commercial bias and based upon all available scientifically rigorous data from research that conforms to accepted standards of experimental design, data collection, and analysis.

Ms Andrews: fees for non-CME/CE services: Genentech.

Dr Hurvitz: contracted research: Ambrx, Amgen, AstraZeneca, Arvinas, Bayer, Cytomx, Daiichi Sankyo, Dignitana, Eli Lilly, Genentech/Roche, Gilead, GlaxoSmithKline, Immunomedics, Macrogenics, Novartis, Pfizer, OBI Pharma, Phoenix Molecular Designs, Ltd, Pieris, Puma Biotechnology, Radius, Sanofi, Seagen, Zymeworks.

None of the members of the Planning Committee or PCE staff have any relevant relationships to disclose.

Instructions for Credit

Participants wishing to earn CE/CME credit must:

  1. Review the content in its entirety
  2. Relate the content material to the learning objectives
  3. Complete the evaluation form

The estimated time to complete this activity is 1.00 hour.

Release date: March 8, 2022
Expiration date: March 7, 2023


Interactive video lecture


The opinions or views expressed in this CE/CME activity do not necessarily reflect the opinions or recommendations of Practicing Clinicians Exchange or any educational supporter.



Joint Accreditation Statement

Joint AccreditationIn support of improving patient care, Practicing Clinicians Exchange is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

ANCC Credit Designation

Nursing contact hours: 1.00, which includes 1.00 hour of pharmacology credit

AAPA Credit Designation

Joint AccreditationPracticing Clinicians Exchange has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credit. Approval is valid until March 7, 2023. PAs should only claim credit commensurate with the extent of their participation.

PA course advisor: Jessica Garner, DMSc, PA-C, University of the Pacific, Sacramento, California

IPCE Credit Designation
IPCEThis activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education (IPCE) credit for learning and change.

Additional Information

Program Medium

This program has been made available online.