ProCE Banner Activity


Progress in Prostate Cancer: A Focus on PARP Inhibitors

Patient Simulation

Recent approval of poly (ADP-ribose) polymerase (PARP) inhibitors as targeted therapy for patients with metastatic castrate-resistant prostate cancer (CRPC) and specific mutations offers a new challenge to healthcare professionals to effectively incorporate these agents into clinical care. This immersive virtual patient simulation activity will help healthcare professionals navigate the use of PARP inhibitors including adverse event management for patients with metastatic CRPC. The activity allows the participant to explore and guide the management of 3 different patient case scenarios.

For a quick review of the key evidence before starting these patient simulations, please see the associated expert commentary and downloadable slideset.

Physician Assistants: maximum of 1.50 hours of AAPA Category 1 CME credits Registered Nurses: 1.50 Nursing contact hours, includes 1.50 hour of pharmacology credit

Released: August 17, 2022

Expiration: August 16, 2023

No longer available for credit.



Brenda Martone

Brenda Martone, MSN, ANP-BC, AOCNP

Nurse Practitioner
Northwestern Medicine
Chicago, Illinois


This activity is supported by educational grants from AstraZeneca; Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC; and Merck Sharp & Dohme Corp.

Provided by

ProCE Banner



Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC

Merck Sharp & Dohme Corp.

Target Audience

Oncology NPs, PAs, and nurses

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify patients with prostate cancer who should undergo mutation testing based on guideline recommendations

  • Consider use of PARP inhibitors in patients with prostate cancer based on safety and efficacy data from pivotal clinical trials

  • Apply recommended monitoring and management strategies for AEs associated with PARP inhibitors


All faculty and planners participating in continuing education activities sponsored by Practicing Clinicians Exchange (PCE) are required to disclose all financial relationships with ineligible companies. All relevant conflicts of interest are thoroughly vetted and mitigated according to PCE policy. In addition, all faculty are required to openly disclose any off-label, experimental, or investigational use of drugs or devices discussed in this activity. The faculty and Planning Committee have been advised that this activity must be free from commercial bias and based upon all available scientifically rigorous data from research that conforms to accepted standards of experimental design, data collection, and analysis.

Brenda Martone, MSN, ANP-BC, AOCNP, has no relevant financial relationships to disclose.

None of the members of the Planning Committee or PCE staff have any relevant financial relationships to disclose.

Instructions for Credit

Participants wishing to earn CE/CME credit must:

  1. Complete the content in its entirety
  2. Relate the content material to the learning objectives
  3. Complete post-test and evaluation form

Successful completion of the post-test is required to earn CE/CME credit. Successful completion is defined as a cumulative score of at least 67%.

The estimated time to complete this activity is 1.50 hours.

Release date: August 17, 2022
Expiration date: August 16, 2022


Patient Simulation

In this virtual simulation platform program, you will meet 3 patients with prostate cancer. The program will have you proceed through your patient’s history, overview of the current situation, and physical exam. It enables you to obtain additional information by ordering laboratory values, imaging, and to make referrals. As the patient scenario warrants, add your recommendations for diagnosis, treatments, and follow-up. End your patient visit and schedule a follow-up. At each end-of-visit, you will see your progress in achieving the predetermined goals for the case. Each case will test your ability to diagnose and prescribe evidence-based recommendations to improve care.


The opinions or views expressed in this CE/CME activity do not necessarily reflect the opinions or recommendations of Practicing Clinicians Exchange or any educational supporter.



Joint Accreditation Statement

Joint AccreditationIn support of improving patient care, Practicing Clinicians Exchange is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

ANCC Credit Designation

Nursing contact hours: 1.50, which includes 1.50 hours of pharmacology credit

AAPA Credit Designation

Joint AccreditationPracticing Clinicians Exchange has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.50 AAPA Category 1 CME credits. Approval is valid until August 16, 2023. PAs should only claim credit commensurate with the extent of their participation.

PA course advisor: Jessica Garner, DMSc, PA-C, University of the Pacific, Sacramento, California

IPCE Credit Designation
IPCEThis activity was planned by and for the healthcare team, and learners will receive 1.50 Interprofessional Continuing Education (IPCE) credits for learning and change.

Additional Information

Program Medium

This program has been made available online.