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An Evidence-Based Approach to Treating Major Depression


Over the past 2 decades, deaths due to suicide have been consistently increasing.  In this activity, an expert reviews unmet needs related to the treatment of depression, evidence supporting the use of atypical antipsychotics as adjunctive therapy, and the role of atypical antipsychotics for the treatment of major depression.

Registered Nurses: 1.00 Nursing contact hours, includes 1.00 hour of pharmacology credit Physician Assistants: maximum of 1.00 hours of AAPA Category 1 CME credits

Released: January 19, 2023

Expiration: January 18, 2024

No longer available for credit.



Amber Hoberg

Amber Hoberg, PMHNP

Nurse Practitioner
MorningStar Family Medicine
Floresville, Texas

Manish K. Jha

Manish K. Jha, MD

Associate Professor of Psychiatry
O'Donnell Clinical Neuroscience Scholar
Center for Depression Research and Clinical Care
UT Southwestern Medical Center
Dallas, Texas

Provided by

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This activity is supported by an educational grant from AbbVie, Inc.

AbbVie Inc.

Target Audience

NPs and PAs

Learning Objectives

After completing this activity, participants should be better able to:

  • Identify the unmet needs in major depression as they relate to current treatment strategies

  • Assess evidence supporting the use of atypical antipsychotics as augmentation therapy in major depression

  • Construct evidence-based patient treatment plans based upon patient and disease state-specific characteristics


All faculty and planners participating in continuing education activities sponsored by Practicing Clinicians Exchange (PCE) are required to disclose all financial relationships with ineligible companies. All relevant conflicts of interest are thoroughly vetted and mitigated according to PCE policy. In addition, all faculty are required to openly disclose any off-label, experimental, or investigational use of drugs or devices discussed in this activity. The faculty and Planning Committee have been advised that this activity must be free from commercial bias and based upon all available scientifically rigorous data from research that conforms to accepted standards of experimental design, data collection, and analysis.

Manish Jha, MD: consultant: Eleusis Therapeutics, Guidepoint Global, Janssen Global Services, Medscape/WebMD, Worldwide Clinical Trials/Eliem Therapeutics; researcher: Acadia, Janssen Research & Development, Neurocrine, Supernus/Navitor.

Greg W. Mattingly, MD: consultant/advisor/speaker: Abbvie, Acadia, Alkermes, Axsome, Corium, Eisai, Ironshore, Intracellular, Janssen, Lundbeck, Neos, Neurocrine, Noven, Otsuka, Redax, Roche, Rhodes, Sage, Sirona, Sunovion, Supernus, Takeda, Teva, Trispharma; researcher: AbbVie, Acadia, Alkermes, Akili, Axsome, Boehringer Ingelheim, Emalex, Idorsia, Janssen, Karuna, Lumos Labs, Medgenics, NLS-1 Pharma AG, Redax, Relmada, Roche, Sage, Sirtsei, Sunovion, Supernus, Takeda, Teva.

Amber Hoberg, PMHNP: consultant: Acadia, Avanir, BioXcel, Intracellular Therapies, Neurocrine, Teva.

Amanda Zimmerman, PA-C: consultant/advisor/speaker: Averitas; researcher: Collegium

The planners and content reviewers from Practicing Clinicians Exchange, do not have any relevant financial relationships to disclose except Greg W. Mattingly, MD, Amber Hoberg, PMHNP and Amanda Zimmerman, PA-C as noted above. 

Instructions for Credit

Learners wishing to earn CE/CME credit must: 

  1. View the content in its entirety
  2. Relate the content material to the learning objectives 
  3. Complete evaluation form 

The estimated time to complete this activity is 1.00 hour.


This program has been made available online.


The opinions or views expressed in this CE/CME activity do not necessarily reflect the opinions or recommendations of Practicing Clinicians Exchange or any educational supporter.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Practicing Clinicians Exchange is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.


ANCC Credit Designation
Nursing contact hours: 1.00, which includes 1.00 hour of pharmacology credit
NP course advisor:
Amber Hoberg, PMHNP, MorningStar Family Medicine, Floresville, Texas

AAPA Credit Designation
Joint AccreditationPracticing Clinicians Exchange has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credit. Approval is valid until January 18, 2024. PAs should only claim credit commensurate with the extent of their participation.

PA course advisor: Amanda Zimmerman, PA-C, West Forsyth Pain Management, Winston-Salem, North Carolina

IPCE Credit Designation
IPCEThis activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education (IPCE) credit for learning and change.