ProCE Banner Activity


Treatment of Bipolar Depression and Mixed Presentations


Mood disorders such as bipolar disorder and depression are often misdiagnosed.  In this activity, an expert describes the continuum of mood disorders from depression to mania, reviews the evidence supporting medications for the treatment of unipolar and bipolar depression, and discusses how to tailor treatment plans based on individual patient and disease state characteristics.

Physician Assistants/Physician Associates: 1.00 AAPA Category 1 CME credit

Nurse Practitioners: 1.00 Nursing contact hours, includes 1.00 hour of pharmacotherapy credit

Released: January 20, 2023

Expiration: January 19, 2024

No longer available for credit.



Charles DeBattista

Charles DeBattista, DMH, MD

Chief, Depression Research Clinic
Director, Medical Student Education in Psychiatry
Professor of Psychiatry and Behavioral Sciences
Stanford University School of Medicine
Stanford, California

Amber Hoberg

Amber Hoberg, PMHNP

Nurse Practitioner
MorningStar Family Medicine
Floresville, Texas

Provided by

ProCE Banner


This activity is supported by educational grants from Intra-Cellular Therapies, Inc.

Intra-Cellular Therapies, Inc.

Target Audience

NPs and PAs

Learning Objectives

After completing this activity, participants should be better able to:

  • Describe the dimensional continuum of mood disorder presentations from unipolar to bipolar disorder

  • Identify evidence supporting the use and limitations of mood-stabilizing drugs and second-generation antipsychotics for the treatment of unipolar and bipolar depression

  • Identify the limitations of monoaminergic antidepressants in bipolar depression and major depression with mixed features 

  • Construct evidence-based patient treatment plans based upon patient and disease state-specific characteristics


All faculty and planners participating in continuing education activities sponsored by Practicing Clinicians Exchange (PCE) are required to disclose all financial relationships with ineligible companies. All relevant conflicts of interest are thoroughly vetted and mitigated according to PCE policy. In addition, all faculty are required to openly disclose any off-label, experimental, or investigational use of drugs or devices discussed in this activity. The faculty and Planning Committee have been advised that this activity must be free from commercial bias and based upon all available scientifically rigorous data from research that conforms to accepted standards of experimental design, data collection, and analysis.

Charles DeBattista, MD: researcher: Biolite, Compass, Janssen, Myriad, Neurocentia, Relamada, Sage; consultant: AbbVie, Corcept.

Amber Hoberg, PMHNP: consultant: Acadia, Avanir, BioXcel, Intracellular Therapies, Neurocrine, Teva.

Roger McIntyre, MD, FRCPC: consultant: Alkermes, Abbvie, Atai Life Sciences, Axsome, Bausch Health, Eisai, Intracellular, Janssen, Kris, Lundbeck, Mitsubishi Tanabe, NewBridge Pharmaceuticals, Neumora Therapeutics, Neurocrine, Novo Nordisk, Otsuka, Pfizer, Purdue, Sanofi, Sunovion, Takeda.

Amanda Zimmerman, PA-C: consultant/advisor/speaker: Averitas; researcher: Collegium.

The planners and content reviewers from Practicing Clinicians Exchange, do not have any relevant financial relationships to disclose except Roger McIntyre, MD, FRCPC, Amber Hoberg, PMHNP and Amanda Zimmerman, PA-C as noted above.

Instructions for Credit

Learners wishing to earn CE/CME credit must: 

  1. View the content in its entirety
  2. Relate the content material to the learning objectives 
  3. Complete evaluation form 

The estimated time to complete this activity is 1.00 hour.


This program has been made available online.


The opinions or views expressed in this CE/CME activity do not necessarily reflect the opinions or recommendations of Practicing Clinicians Exchange or any educational supporter.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Practicing Clinicians Exchange is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.



ANCC Credit Designation
Nursing contact hours: 1.00, which includes 1.00 hour of pharmacology credit
NP Course Advisor:
Amber Hoberg, PMHNP, MorningStar Family Medicine, Floresville, Texas


AAPA Credit Designation
Joint AccreditationPracticing Clinicians Exchange has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credit. Approval is valid until January 19, 2024. PAs should only claim credit commensurate with the extent of their participation.

PA course advisor: Amanda Zimmerman, PA-C, West Forsyth Pain Management, Winston-Salem, North Carolina

IPCE Credit Designation
IPCEThis activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education (IPCE) credit for learning and change.