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APP Perspectives: Managing Toxicities With Bispecific Antibodies in Multiple Myeloma

Text Module

Read this text module to learn key strategies for identifying, preventing, and managing adverse events associated with bispecific antibody therapy in multiple myeloma, with a focus on the advanced practice provider perspective. This module outlines expert recommended supportive care and monitoring considerations for common BCMA and GPRC5D bispecific antibody treatment–related adverse events, including CRS, ICANS, infections, and others, emphasizing the importance of multidisciplinary coordination to optimize patient safety and treatment outcomes between academic and community settings.

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Nurse Practitioners/Nurses: 0.50 Nursing contact hour

Released: November 07, 2025

Expiration: May 06, 2026

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Provided by Clinical Care Options, LLC.

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Supporters

Supported by an educational grant from Johnson & Johnson.

Johnson & Johnson

Target Audience

This activity is intended for oncology nurses and nurse practitioners, physician associates, and other healthcare professionals involved in caring for patients with multiple myeloma.

Program Learning Goal

This activity aims to improve learners' knowledge, competence, and performance in improving the comprehensive care of patients with R/R MM receiving bispecific antibody therapy.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Discuss bispecific antibody-based therapeutic strategies with patients with multiple myeloma and their caregivers, taking into consideration current indications, safety profiles, dosing protocol considerations, and patient goals and preferences

  • Manage and mitigate adverse events associated with bispecific antibody treatment in patients with multiple myeloma

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Charise Gleason, MSN, NP-C, AOCNP, has no relevant financial relationships to disclose.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from November 07, 2025, through May 06, 2026:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Nursing Continuing Professional Development

The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.5 contact hours.

Physician Associate Continuing Medical Education

AAPA CME Accreditation - AAPA

Clinical Care Options, LLC has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits. Approval is valid until May 06, 2026. PAs should only claim credit commensurate with the extent of their participation.