Can Leading a Healthy Lifestyle Change the Likelihood of Developing Systemic Lupus Erythematosus?

Can Leading a Healthy Lifestyle Change the Likelihood of Developing Systemic Lupus Erythematosus? Posted By:
...

An abstract presented at this year's American College of Rheumatology (ACR) conference asked whether the likelihood of being diagnosed with systemic lupus erythematosus (SLE) in the future could be modified by healthy lifestyle behavior. The abstract analyzed data using the Nurses' Health Study (NHS) I (1976-2016) and NHS II (1989-2017) and looked at three lifestyle behaviors to calculate a Healthy Lifestyle Index Score (HLIS). The data were captured at the beginning of the study and biennially thereafter.

The three lifestyle behaviors analyzed were alcohol intake, body mass index (BMI), and smoking status. Low risk/"healthy" behaviors were described as: "moderate" intake of alcohol, defined as 5 g to 15 g per day (~12 oz of beer, 1.5 oz of hard liquor, or 5 oz of wine); never smoking or quitting more than 4 years previously; and BMI of 18.5 to 24.9 kg/m2. The study included 217,623 female nurses. There were 283 incident SLE cases during 5,815,233 person-years of follow-up. The findings showed that a higher HLIS was associated with a lower SLE risk overall (HR 0.75 [95% CI 0.64-0.88]). Women who consumed "moderate" amounts of alcohol had a lower risk of developing SLE compared with those who consumed less alcohol (HR 0.62 [95% CI 0.46-0.83]). In addition, women who were never smokers or who had quit more than 4 years ago were less likely to develop anti-double stranded (ds) DNA positive SLE (HR 0.55 [95% CI 0.36-0.85]) compared with current smokers and those who had quit within the last 4 years.

In the final analysis, women who were able to follow all three lifestyle behaviors had a 43% lower risk of developing SLE than those who were not. However, the population studied was all female, and therefore we cannot extrapolate the impact of these lifestyle behaviors to men. In addition, the reviewers noted the impact of poverty and its attendant issues could not be studied in this cohort. Nonetheless, I was surprised to learn that healthy lifestyles could significantly reduce development of SLE. Going forward, it seems that patients who have a positive family history of SLE and/or those who are antinuclear antibody-positive and dsDNA-positive could have a 43% lower risk of developing SLE if they follow the three lifestyle behaviors described above.

References

Share

Filed under: Preventive Medicine , Rheumatology

Related
Doxy-PEP: A New Opportunity to Reduce STIs

Doxy-PEP: A New Opportunity to Reduce STIs

According to CDC data from 2022, more than 2.5 million cases of chlamydia, gonorrhea, and syphilis w ...

Filed under: Nurses Week, Infectious Diseases, Urology, Preventive Medicine, Public Health, Substance Abuse, NPs & PAs


Continue Reading
Navigating Nonpharmacologic Approaches to Chronic Pain Management

Navigating Nonpharmacologic Approaches to Chronic ...

The concept of multimodal treatment in chronic pain management goes back to some of the early establ ...

Filed under: Psychiatry, Preventive Medicine, Public Health, Substance Abuse, NPs & PAs


Continue Reading
Tackling Disparities in HIV Prevention

Tackling Disparities in HIV Prevention

Racial and ethnic disparities have been a problem in the HIV epidemic since the very beginning. Rece ...

Filed under: Infectious Diseases, Women's Health, Preventive Medicine, Public Health, NPs & PAs


Continue Reading
Strategies for APPs in Primary Care: Promoting PrEP Uptake Among Cisgender Women

Strategies for APPs in Primary Care: Promoting PrE ...

As a family nurse practitioner and a researcher at the University of Pennsylvania and Thomas Jeffers ...

Filed under: Infectious Diseases, Women's Health, Preventive Medicine, Public Health, NPs & PAs


Continue Reading
Dupilumab Now Approved for Eosinophilic Esophagitis

Dupilumab Now Approved for Eosinophilic Esophagiti ...

Eosinophilic esophagitis (EoE) is a gastrointestinal disorder characterized by eosinophilic inflamma ...

Filed under: Gastroenterology, Preventive Medicine


Continue Reading
Universal Screening for Afib in Primary Care: Feasible but not Productive

Universal Screening for Afib in Primary Care: Feas ...

Recent data from the VITAL-AF study has provided insight into the efficacy of universal point-of-car ...

Filed under: Cardiometabolic, Preventive Medicine


Continue Reading