The Exchange

Commentary and Observations from
the Medical Front Lines

Amanda Michaud, MMS, PA-C

Amanda Michaud, MMS, PA-C

  • Physician Assistant
  • Arizona Asthma and Allergy Institute
  • Scottsdale, Arizona
Impact of Prenatal and Early-life Pollution Exposure on Development of Asthma in Children

Impact of Prenatal and Early-life Pollution Exposure on Development of Asthma in Children

Research suggests an association of early-life pollution exposure and the development of asthma in childhood. Perinatal exposure to a variety of pollutants such as nitric oxide, ozone, and particulate matter has been reported to increase the likelihood of developing allergic disease and asthma.

A recent cohort study by Zhang et al shows that prenatal and early-life exposure to particulate matter less than 10 μm in diameter was associated with increased risk of development of asthm... Continue Reading

Filed under: Allergy/Immunology, Public Health

Prenatal Vitamin D Supplementation and the Development of Allergic Disease

Prenatal Vitamin D Supplementation and the Development of Allergic Disease

It is suggested that the increasing prevalence of vitamin D insufficiency worldwide could be a factor in the rising rates of allergic rhinitis, atopic diseas... Continue Reading

Filed under: Allergy/Immunology, Women's Health

Non-Infectious Complications of Common Variable Immunodeficiency

Non-Infectious Complications of Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is the most common type of symptomatic primary immune deficiency disorder, affecting approximately 1 out of every 25,... Continue Reading

Filed under: Allergy/Immunology

Diagnosis and Management of Hereditary Angioedema

Diagnosis and Management of Hereditary Angioedema

Hereditary angioedema (HAE) is an autosomal-dominant disorder caused by deficiency of C1 esterase inhibitor (C1-INH). It is estimated that HAE affects 1 out... Continue Reading

Filed under: Allergy/Immunology

What to Do With Patients who Report Allergic Symptoms Following the First Dose of an mRNA COVID-19 Vaccine

What to Do With Patients who Report Allergic Symptoms Following the First Dose of an mRNA COVID-19 Vaccine

A major concern to public health officials is incomplete vaccination with the mRNA COVID-19 vaccine series. One reason for incomplete vaccination is if patie... Continue Reading

Filed under: Allergy/Immunology, Infectious Diseases, Preventive Medicine

A New Biologic on the Horizon for Severe Asthma

A New Biologic on the Horizon for Severe Asthma

There are currently 5 available monoclonal antibody treatments for patients with moderate to severe asthma, all of which target immunoglobulin E (IgE) or typ... Continue Reading

Filed under: Allergy/Immunology, Pulmonary Medicine

Identification and Management of Chronic Rhinosinusitis

Identification and Management of Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) has an estimated prevalence of up to 5% of the population. By definition, CRS is a chronic inflammatory condition of the paranas... Continue Reading

Filed under: Allergy/Immunology

Contact Dermatitis Diagnosis and Management: When to Refer for Patch Testing

Contact Dermatitis Diagnosis and Management: When to Refer for Patch Testing

Contact dermatitis (CD) is a relatively common inflammatory skin condition, grouped with occupational skin disease. CD usually presents with erythematous and... Continue Reading

Filed under: Allergy/Immunology

Stinging Insect Allergy

Stinging Insect Allergy

Stinging insect allergy accounts for 10% of all cases of anaphylaxis. Stings from flying hymenopterans and fire ants are responsible for most cases. Approxim... Continue Reading

Filed under: Allergy/Immunology

Food Protein-Induced Enterocolitis Syndrome (FPIES)

Food Protein-Induced Enterocolitis Syndrome (FPIES)

Food protein-induced enterocolitis syndrome (FPIES) is a non–immunoglobulin (Ig) E-mediated food allergy that typically presents in infants. The most commo... Continue Reading

Filed under: Allergy/Immunology

Management of Severe T2-High Asthma

Management of Severe T2-High Asthma

Many patients with asthma have type 2 inflammation. Type 2 inflammation, also known as T2-high asthma, is driven by presence of interleukin (IL)-4, IL-5, IL-... Continue Reading

Filed under: Allergy/Immunology, Pulmonary Medicine

Diagnostics in Food Allergy

Diagnostics in Food Allergy

Food allergy is a growing public health concern and its prevalence is increasing worldwide. The most common food allergens—milk, egg, soy, wheat, peanut, t... Continue Reading

Filed under: Allergy/Immunology, Public Health

Diagnosis and Management of Chronic Idiopathic Urticaria

Diagnosis and Management of Chronic Idiopathic Urticaria

Chronic idiopathic urticaria (CIU), also called chronic spontaneous urticaria (CSU), is a condition when urticaria, or hives, are present for more than 6 wee... Continue Reading

Filed under: Allergy/Immunology, Dermatology

Why Your Patient Probably Isn’t Allergic to Penicillin

Why Your Patient Probably Isn’t Allergic to Penicillin

Drug allergies are documented in more than 20% of electronic health records throughout the world, with antibiotic allergies being the most commonly reported.... Continue Reading

Filed under: Allergy/Immunology

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