The Exchange

Commentary and Observations from
the Medical Front Lines

Latest Allergy/Immunology Articles on PCE's The Exchange

Non-Infectious Complications of Common Variable Immunodeficiency

Non-Infectious Complications of Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is the most common type of symptomatic primary immune deficiency disorder, affecting approximately 1 out of every 25,000 persons. The most recent guidelines suggest CVID in the presence of the following: low immunoglobulin (Ig) G levels, based on age; either low IgM or IgA; poor antibody response after vaccination; older than 4 years of age; and no secondary causes of hypogammaglobulinemia. Secondary causes of hypogammaglobulinemia can include liver dis... Continue Reading

Filed under: Allergy/Immunology

Diagnosis and Management of Hereditary Angioedema

Diagnosis and Management of Hereditary Angioedema

Hereditary angioedema (HAE) is an autosomal-dominant disorder caused by deficiency of C1 esterase inhibitor (C1-INH). It is estimated that HAE affects 1 out... Continue Reading

Filed under: Allergy/Immunology

What to Do With Patients who Report Allergic Symptoms Following the First Dose of an mRNA COVID-19 Vaccine

What to Do With Patients who Report Allergic Symptoms Following the First Dose of an mRNA COVID-19 Vaccine

A major concern to public health officials is incomplete vaccination with the mRNA COVID-19 vaccine series. One reason for incomplete vaccination is if patie... Continue Reading

Filed under: Allergy/Immunology, Infectious Diseases, Preventive Medicine

A New Biologic on the Horizon for Severe Asthma

A New Biologic on the Horizon for Severe Asthma

There are currently 5 available monoclonal antibody treatments for patients with moderate to severe asthma, all of which target immunoglobulin E (IgE) or typ... Continue Reading

Filed under: Allergy/Immunology, Pulmonary Medicine

Identification and Management of Chronic Rhinosinusitis

Identification and Management of Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) has an estimated prevalence of up to 5% of the population. By definition, CRS is a chronic inflammatory condition of the paranas... Continue Reading

Filed under: Allergy/Immunology

Contact Dermatitis Diagnosis and Management: When to Refer for Patch Testing

Contact Dermatitis Diagnosis and Management: When to Refer for Patch Testing

Contact dermatitis (CD) is a relatively common inflammatory skin condition, grouped with occupational skin disease. CD usually presents with erythematous and... Continue Reading

Filed under: Allergy/Immunology

Using Biologic Therapy for Moderate to Severe Atopic Dermatitis

Using Biologic Therapy for Moderate to Severe Atopic Dermatitis

As mentioned in my previous post this week, atopic dermatitis (AD) affects more than 9.6 million children and about 16.5 million adults in the United States.... Continue Reading

Filed under: Allergy/Immunology, Dermatology

The Atopic Triad: Why It’s So Important to Collaborate With Colleagues

The Atopic Triad: Why It’s So Important to Collaborate With Colleagues

As spring approaches, there is an entire subset of seasonal medical problems that can affect our patients. Especially in dermatology, it is quite common at t... Continue Reading

Filed under: Allergy/Immunology, Dermatology

Stinging Insect Allergy

Stinging Insect Allergy

Stinging insect allergy accounts for 10% of all cases of anaphylaxis. Stings from flying hymenopterans and fire ants are responsible for most cases. Approxim... Continue Reading

Filed under: Allergy/Immunology

Food Protein-Induced Enterocolitis Syndrome (FPIES)

Food Protein-Induced Enterocolitis Syndrome (FPIES)

Food protein-induced enterocolitis syndrome (FPIES) is a non–immunoglobulin (Ig) E-mediated food allergy that typically presents in infants. The most commo... Continue Reading

Filed under: Allergy/Immunology

Management of Severe T2-High Asthma

Management of Severe T2-High Asthma

Many patients with asthma have type 2 inflammation. Type 2 inflammation, also known as T2-high asthma, is driven by presence of interleukin (IL)-4, IL-5, IL-... Continue Reading

Filed under: Allergy/Immunology, Pulmonary Medicine

Diagnostics in Food Allergy

Diagnostics in Food Allergy

Food allergy is a growing public health concern and its prevalence is increasing worldwide. The most common food allergens—milk, egg, soy, wheat, peanut, t... Continue Reading

Filed under: Allergy/Immunology, Public Health

Will You Get a COVID-19 Vaccine?

Will You Get a COVID-19 Vaccine?

In a post earlier this week, I wrote about public skepticism concerning COVID-19 vaccines, with some surveys showing an estimated 50-50 split in terms of whe... Continue Reading

Filed under: Allergy/Immunology, Health Policy and Trends, Infectious Diseases, Preventive Medicine, Public Health

COVID-19 Vaccine Trials: Reality Check

COVID-19 Vaccine Trials: Reality Check

There is both good and bad news with respect to the ongoing COVID-19 vaccine trials. As a preface, know that approximately 90% of vaccine trials fail to lead... Continue Reading

Filed under: Allergy/Immunology, Infectious Diseases, Preventive Medicine, Public Health

Diagnosis and Management of Chronic Idiopathic Urticaria

Diagnosis and Management of Chronic Idiopathic Urticaria

Chronic idiopathic urticaria (CIU), also called chronic spontaneous urticaria (CSU), is a condition when urticaria, or hives, are present for more than 6 wee... Continue Reading

Filed under: Allergy/Immunology, Dermatology

Why Your Patient Probably Isn’t Allergic to Penicillin

Why Your Patient Probably Isn’t Allergic to Penicillin

Drug allergies are documented in more than 20% of electronic health records throughout the world, with antibiotic allergies being the most commonly reported.... Continue Reading

Filed under: Allergy/Immunology

Would You Volunteer to Enroll in a COVID-19 Vaccine Trial?

Would You Volunteer to Enroll in a COVID-19 Vaccine Trial?

There are more than 160 COVID-19 vaccines currently in development, with the University of Oxford/AstraZeneca AZD1222 vaccine (an attenuated altered adenovir... Continue Reading

Filed under: Allergy/Immunology, Infectious Diseases, Public Health

Asthma Q&A With Dr Kurtis Elward: Part 2

Asthma Q&A With Dr Kurtis Elward: Part 2

PCE recently held our Series 1 Live Stream events. During the Live Streams, attendees have the chance to ask expert faculty specific questions, though we oft... Continue Reading

Filed under: Allergy/Immunology, Pulmonary Medicine

Asthma Q&A With Dr Kurtis Elward: Part 1

Asthma Q&A With Dr Kurtis Elward: Part 1

PCE recently held our Series 1 Live Stream events. During the Live Streams, attendees have the chance to ask expert faculty specific questions, though we oft... Continue Reading

Filed under: Allergy/Immunology, Pulmonary Medicine

Measles and Immunity

Measles and Immunity

Measles is a highly contagious viral illness, currently targeted for eradication given the favorable biologic characteristic that humans are the only reservo... Continue Reading

Filed under: Allergy/Immunology, Infectious Diseases

Universal Influenza Vaccine Begins Phase I Clinical Trials

Universal Influenza Vaccine Begins Phase I Clinical Trials

The National Institutes of Health have begun the first clinical trial of an innovative universal influenza vaccine candidate. A Phase I trial will examine th... Continue Reading

Filed under: Allergy/Immunology, Health Policy and Trends, Public Health

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