eCase - Managing TNBC

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Cases and Challenges in the Optimal Treatment of Triple-Negative BC

Jeremy M. Force, DO

Activity

Which of these is a newer option for patients with early-stage TNBC?

Which of the following patients with mTNBC would be eligible for sacituzumab govitecan per its current FDA indication?

Which of these is the most common grade 3 or 4 toxicity associated with PARP inhibitors?

Valerie, 50, has TNBC with metastatic progression 2 years after completing adjuvant chemotherapy. She had no molecular testing at diagnosis. What molecular testing should be done to guide her next line of treatment?

Valerie began treatment with pembrolizumab + chemotherapy for recurrent mTNBC. At follow-up 11 months later, scans show progression in Valerie’s lung tumors. What do you tell her is a next step?

Rene, 42, was diagnosed with stage III TNBC. She is BRCA-negative, PD-L1 CPS 5 and is being treated with neoadjuvant pembrolizumab + chemotherapy. She has developed grade 1 hypothyroidism. How do you manage this?