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Histology in CD
Interactive Case Challenge 3: Evolving Role of Histology in Crohn’s Disease Management 

Released: March 18, 2025

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Case History and Presentation 
Three months later, Mr Smith returns for follow-up with improved symptoms. He reports his abdominal pain has decreased and his stools reduced to 1-2 daily. Labs show that CRP decreased to 5 mg/L and fecal calprotectin decreased to 110 µg/g. Repeat colonoscopy shows no new mucosal ulcers, SES-CD improved from 10 to 4.

What is the next best step in Mr Smith’s management now that his symptoms and biomarkers have improved?